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Structures


PROTEOPEDIA -- LIFE IN 3-D -- Articles in Category Kovari, L.C.

 

 Multi-Drug Resistant HIV-1 Protease

Co-crystal structures of darunavir and tipranavir with the multi-drug resistant protease. (A) The tipranavir-MDR 769 82T structure (magenta) was superimposed in the tipranavir-WT protease structure (green). (B)The conformational changes of darunavir binding to MDR 769 82T (magenta) in comparison with the darunavir-WT HIV-1 protease complex (green). Pubmed: 21871444

 

Structure of the MDR 769 HIV-1 protease MA/CA complex. The two protease monomers are shown in ribbon rendering. The MA/CA substrate peptide is shown by stick model. Pubmed: 21394574

 

"Wide-Open" 1.3 Å  structure of multidrug-resistant 769 HIV-1 Protease. This structure represents an opening that is 8Å wider than the "open" structure of the wild-type protease. Pubmed: 16338417

 

HIV-1 protease comparison of MDR isolate 769 and the wild type complexed with lopinavir. The wild-type HIV-1 protease and the lopinavir molecule are shown in green. The MDR 769 protease variant and its respective lopinavir molecule are shown in red. Pubmed: 14990731

   

Myelin Protein Zero

Crystal structure of the fusion protein MBP- MPZex. In green, is the closed-form of MBP with a maltose molecule, and human myelin protein zero extracellular domain is shown in blue. The linker connecting MBP and the MPZex is presented by a dotted line. Pubmed: 21971831

              

 

 Structures Deposited in the RCSB Protein Data Bank

www.rcsb.org

4FAF Fully Closed MDR HIV-1 Protease with Substrate Peptide CA/p2

4FAE Fully Closed MDR HIV-1 Protease with Substrate Peptide p2/NC

3ROW MDR HIV-1 Protease with Aspartyl Protease Inhibitor RSY

3ROY MDR HIV-1 Protease with Aspartyl Protease Inhibirtor RSZ

3SO9 MDR HIV-1 Protease with Darunavir

3SPK MDR HIV-1 Protease with Tipranavir

3OQ7 MDR HIV-1 Protease A82T

3OQA MDR HIV-1 Protease T82S

3OQD MDR HIV-1 Protease T82F

3PJ6 MDR HIV-1 Protease

3OTS MDR HIV-1 Protease with Substrate Peptide MA/CA

3OTY MDR HIV-1 Protease with Substrate Peptide RT/RH

3OU1 MDR HIV-1 Protease with Substrate Peptide RH/IN

3OU3 MDR HIV-1 Protease with Substrate Peptide PR/RT

3OU4 MDR HIV-1 Protease with Substrate Peptide TF/PR

3OUA MDR HIV-1 Protease with Substrate Peptide p1/p6

3OUB MDR HIV-1 Protease with Substrate Peptide NC/p1

3OUC MDR HIV-1 Protease with Substrate Peptide p2/NC

3OUD MDR HIV-1 Protease with Substrate Peptide CA/p2

1TW7 MDR HIV-1 Protease

1RV7 HIV-1 Protease with Lopinavir

1RP1 HIV-1 Protease with Glucose

1RQ9 HIV-1 Protease with DMP450

1TQ3 PDZ domain of Presynaptic Density Protein 95

1TP3 PDZ domain of Presynaptic Density Protein 95 with Peptide KKETPV

1TP5 PDZ domain of Presynaptic Density Protein 95 with Peptide KKETWV

1AFV HIV-1 Capsid Protein with FAB 25.3

3OAI Human Myelin Protein Zero Extracellular Domain

 

 

 

 

 

 

 

 

 


Dr. Ladislau C. Kovari Wayne State University School of Medicine Dept. of Biochemistry and Molecular Biology 540 E. Canfield Avenue Detroit, MI 48201
E-mail: kovari@med.wayne.edu Tel: 313-577-0296 (lab) Tel: 313-993-1335 (office) Fax: 313-577-2765